Then, we detected their expression in RCC tissues and found 6 (MMP14, ZNF384, BAZ2A, EFNA1, MEF2D and MAX) were significantly up-regulated in tumor tissues based on TCGA KIRC database and the Clinical Proteomic Tumor Analysis Consortium (CPTAC) ccRCC Dataset 30 (Figure S4A-B). This evidence concerns the gene MMP14 and renal cell carcinoma.