MYC and pachyonychia congenita: Our findings validated this therapy in vitro and in vivo, suggesting that targeted epigenetic therapies using dCas9-sgLINC00261 as a promising epigenetic drug target may be an alternate strategy for the treatment of PC, because this approach can restore the expression of LINC00261 and produce tumor inhibitory effects via c-Myc, ultimately improving the clinical prognosis of patients.