To investigate the effect of LINC00261 on the malignant phenotypes of PC cells, we first assessed LINC00261 expression in four PC cell lines and performed gain- and loss-of-function studies in PC cells by constructing a LINC00261 overexpression vector and LINC00261-siRNA (Figure S3A-E). Here, LINC00261 is linked to pachyonychia congenita.