To confirm this hypothesis, we first depleted CD8+ T cells or B cells in immunocompetent C57BL/6 mice using depleting antibodies, and flow cytometry analysis showed an extremely low percentage of CD8+ or CD19+ cells in the total CD45+ spleen lymphocyte population in these mice on day 31 post tumor inoculation (Figure 8A). The gene discussed is PTPRC; the disease is neoplasm.