Furthermore, in vivo neutralization of CXCL10 or CXCL13 dampened the therapeutic effect of abemaciclib (Figure 6B-C), indicating that CXCL10-mediated CD8+T cell infiltration and CXCL13-mediated B cell infiltration paly crucial roles in abemaciclib induced tumor suppression. Here, CD8A is linked to neoplasm.