EGFR and head and neck squamous cell carcinoma: Because basal-like HNSCC aberrantly expresses factors involved in EGFR signaling, including the upregulated expression of the EGFR ligand epiregulin, the authors proposed that the sensitivity of basal-like cells to EGFR blockade results from their addiction to an oncogenic autoamplifying loop characterized by high expression of epiregulin and amphiregulin.