BCL2 and cancer: Several GQs in the promoter regions present upstream of proto-oncogenes represent the six hallmarks of cancer 6 including C-MYC, C-KIT and KRAS (self-sufficiency), RB1 (insensitivity), BCL-2 (evasion of apoptosis), VEGFA (angiogenesis), hTERT (limitless replication) and PDGFA (metastasis) and these GQs can be targeted by suitably designed ligands to regulate their expression 5, 7.