Many other lncRNAs have also been reported to be capable of regulating PI3K/AKT/mTOR pathway, such as PTENP1 92, 93, MALAT1 94 and Xist 95, indicating the possible involvement of these lncRNAs in regulating resistance to the targeted therapies in BC (Figure 4A). The gene discussed is XIST; the disease is breast cancer.