Besides, a CRISPR/Cas9-based synergistic activation mediator (SAM) system has been developed and identified lncRNA AK023948 as a positive AKT regulator in BC through interacting with ATP-dependent RNA helicase A (RHA/DHX9) and p85 to sustain the stability of p85 90 (Figure 4A). The gene discussed is AKT1; the disease is breast cancer.