TRIB3 and acute promyelocytic leukemia: Importantly, ATRA treatment induced increased serum TG levels in Pml-Rarα transgenic mice but did not elevate TG levels in Trib3-knockout Pml-Rarα transgenic mice (PR-T3KO) (Figure 7L & M), indicating that TRIB3 is involved in the regulation of anti-APL-therapy-induced dyslipidemia in individuals with APL.