Our recent work indicates that elevated TRIB3 expression stabilizes the oncoproteins PML-RARα and PML in APL 23, 24 and that PML exerts its essential role in breast cancer cell and hepatic stellate cell (HSC) maintenance through regulation of PPAR signaling and fatty acid oxidation (FAO) 36, 37. The gene discussed is TRIB3; the disease is acute promyelocytic leukemia.