To verify whether the adipokine resistin secreted from APL cells could enhance lipid levels in hepatocytes, we treated normal liver cells with resistin (Figure 3G) and found that resistin stimulation lowered LDLR expression in hepatocytes and enhanced the levels of TG, TC and PCSK9 in the culture supernatants of hepatocytes (Figure 3H-I). The gene discussed is RETN; the disease is acute promyelocytic leukemia.