PML and acute promyelocytic leukemia: Serum TG, HDL, and LDL levels were higher in 3- to 4-month-old Pml-RarαKI mice (no APL symptoms) than in wild-type (WT) mice of the same age (Figure 2F-H), indicating that PML-RARα plays a critical role in the lipid metabolism disorder associated with APL.