In contrast, in mice treated with HDIs, E-cadherin expression was downregulated compared with controls, and when mice were treated with HDIs combined with AS, the E-cadherin expression in tumor tissue was elevated close to that of the control group (Figure S), demonstrating that HDIs could promote EMT and the FOXO1 inhibitor AS could inhibit HDI-induced EMT in vivo. This evidence concerns the gene FOXO1 and neoplasm.