For instance, KDM6B could promote TGF-β-induced epithelial-mesenchymal transition (EMT) through activating SNAI1 in breast cancer cells 42, and instigate proliferative, metastatic, and self-renewal capacities of tumor cells in liver, ovarian, and skin cancers by modulating multiple signalings 24, 43, 44. Here, TGFB1 is linked to skin cancer.