On the other side, the tumor-suppressive role of KDM6B was supported by the evidence showing that it is a key activator of the INK4a/ARF tumor suppressor locus in response to oncogenic stress such as RAS activation 45 and it is involved in the epigenetic regulation of cis-regulatory elements activated during DNA damage response in a p53-dependent manner 35. The gene discussed is CDKN2A; the disease is neoplasm.