KDM6A and cancer: We noticed that some of the SE-associated genes repressed by GSK-J4 treatment are well-known critical regulators of cancer cell stemness, such as ID126, 27 and TERT28, and further confirmed their downregulation by GSK-J4 or shRNAs targeting KDM6A or KDM6B in two CRC cell lines (Figure 5F-G and Figure S2C-D).