For instance, GSK-J4 strongly inhibits the growth of pediatric brainstem glioma bearing histone H3.3 K27M mutation through restoring global H3K27me3 level 15, sensitizes diffuse intrinsic pontine glioma to radiation therapy by repressing the expression of DNA repair genes 16, and induces differentiation of neuroblastoma accompanied by upregulation of apoptosis-promoting gene PUMA 18. The gene discussed is BBC3; the disease is diffuse intrinsic pontine glioma.