EP300 and cancer: In accordance with our findings, being a core member of a COMPASS (Complex Proteins Associated with Set1) -like transcription activator complex containing H3 lysine 4 methyltransferases MLL2/3 and histone acetyl transferase p300 29, KDM6A has been implicated in shaping enhancers and remodeling chromatin in developmental and physiological processes such as cell lineage determination 30 and mounting of innate immune response 31 and also in disease conditions including cancer 32, 33.