Importantly, migration and tube formation abilities of HUVECs were indeed attenuated when treated with CM derived from reconstituted ZNF322A/siShh lung cancer cells (panel 4) compared with those from ZNF322A overexpressing lung cancer cells (panel 3, Figure 4A and 4B), suggesting that Shh is a downstream effector of ZNF322A-mediated pro-angiogenesis. Here, SHH is linked to lung carcinoma.