In vitro HUVEC transwell migration (Figure 4A) and tube formation (Figure 4B) assays showed that si-Shh in H460 KrasQ61H lung cancer cells inhibited HUVECs migration (panel 2), whereas overexpression of ZNF322A promoted HUVECs migration (panel 3) compared with control group (panel 1, Figure 4A and 4B). This evidence concerns the gene SHH and lung cancer.