IGHE and Alzheimer disease: In dermatology, adipose tissue-derived MSC-EVs attenuated pathological symptoms in an AD mouse model, reducing clinical scores levels of IgE and eosinophils in the blood, the infiltration of immune cells in skin lesions, and the mRNA expression of various inflammatory cytokines 123, which indicated that MSC-EVs could be a novel and promising therapeutic strategy for AD treatment.