In our NASH-HCC model, an aggressive growth pattern of tumor nodules was detected in the FGF21KO mice with a single injection of DEN and HFMCD feeding, while HCC lesions, in terms of nodule number and nodule size, was significantly alleviated when the animals were treated with anti-IL-17A antibody. Here, IL17A is linked to metabolic dysfunction-associated steatohepatitis.