The results indicated that inhibition of TLR4 attenuated significantly the expressions of IKKα, IKKβ, p-IκB/IκB, and p-NF-κB/NF-κB in the isolated hepatocytes from liver tissues of NASH model (Figure 4B). The gene discussed is NFKB1; the disease is metabolic dysfunction-associated steatohepatitis.