Consequently, the important components (FASN, PPARα, FGF21, IL-17A, IL-17RA, p-YAP TAZ and TLR4) related to the HCC carcinogenetic transformation were further evaluated by Western blot in the paired human samplers (malignant versus benign) of HCC patients. The gene discussed is PPARA; the disease is hepatocellular carcinoma.