AXL and melanoma: For example, Tirosh et al.5 applied single-cell RNA sequencing (scRNA-seq) to human melanoma and identified two groups of malignant cells with high expression of the microphthalmia-associated transcription factor (MITF) gene: a master melanocyte transcriptional regulator group (MITF-high cells) and a group expressing the AXL gene conferring resistance to targeted therapies (AXL-high cells).