ATG4B and neoplasm: Yang et al. used a genetically engineered mouse model of pancreatic cancer expressing the inducible dominant-negative form of ATG4B (ATG4BC74A) to show that the tumour regression induced by inhibition of autophagy was at least in part immune mediated.40 The authors observed an increase in the infiltration of macrophages (but not T cells) in the tumours upon inhibition of autophagy, and this was associated with increased anti-tumour activity.