KRAS and familial pancreatic carcinoma: A 2019 study by Görgülü et al. investigated the impact of Atg5 gene dosage in a  Kras-mutant model of pancreatic cancer.39 Homozygous deletion of Atg5 led to enhanced acinar-to-ductal metaplasia, but lesions failed to progress to high-grade PanIN lesions and PDAC.