ATG5 and neoplasm: DeVorkin et al. reported increased anti-tumour efficacy, despite decreased overall T-cell infiltration, with autophagy-deficient T cells generated using genetic ablation of key autophagy genes (ATG5, ATG16L and ATG14) and bone marrow transplant (to specifically study the effect in leucocytes/bone-marrow-derived cells).75 Interestingly, the observations of the epigenetic landscape of T cells in this study, in terms of autophagy induction and inhibition of T-cell maturation, mirror those made by Vodnala et al., which is reassuring.