Previous clinicopathological studies demonstrated that PD-L1 expression level within tumor cells was closely correlated with 18F-FDG uptake10–12; therefore, the accumulation of 18F-FDG may be expected to predict the efficacy of anti-PD-1 antibody, similar to the role of PD-L1 expression as a predictive marker. The gene discussed is CD274; the disease is neoplasm.