In order to potentially replicate OM GWAS findings for PLG, the c.112A > G (p.Lys38Glu), c.782G > A (p.Arg261His), c.1481C > T (p.Ala494Val), c.2045 T > A (p.Ile682Asn), and c.1414G > A (p.Asp472Asn) variants were Sanger-sequenced in 314 US trios with OM. The gene discussed is PLG; the disease is ocular melanoma.