As one of the chief components of the ECM, hyaluronic acid contributes significantly to inflammation,105 wound healing,106 granulation tissue formation,107 proliferation, and migration.108 CHI3L1, along with hyaluronic acid, is increasingly being acknowledged as an effective, non-invasive biomarker for the diagnosis of hepatic fibrosis.109 The amino-acid sequence analysis indicated that CHI3L1 contains two potential hyaluronic acid-binding motifs (residues 147–155 and 369–377) on the external face of the folded protein, but this warrants further evaluation using crystallization studies.66,99. This evidence concerns the gene CHI3L1 and Hepatic fibrosis.