30,68 In mammalian lung fibrosis CHI3L1 plays a profibrotic role in the repair phase by augmenting alternative macrophage activation, fibroblast proliferation, and matrix deposition.163 Additionally, CHI3L1 exacerbates HPS-associated pulmonary fibrosis through binding to CRTH2 receptor.31,97 Serum CHI3L1 levels are also increased in patients with cystic fibrosis164 as well as asbestosis.165. This evidence concerns the gene CHI3L1 and asbestosis.