CHI3L1 and cancer: CHI3L1 inhibition by shRNA increases cell death triggered by several anticancer drugs, including cisplatin, etoposide, and doxorubicin, whereas overexpressed CHI3L1 exhibits the opposite effect in glioblastoma U87 MG cells.41 Particularly in late-stage glioblastoma, CHI3L1 regulates tumorigenesis by interrupting the pathways leading to apoptosis.6 Additionally, CHI3L1 also protects cancer cells from apoptosis by remodeling the ECM to create a good substrate for tumor growth and progress.71