CHI3L1 and obesity due to melanocortin 4 receptor deficiency: CHI3L1 expression is greatly enhanced during Th2 inflammatory responses induced by ovalbumin, aluminum hydroxide, house dust, and mites, while CHI3L1 knockout mice exhibit reduced Th2 inflammation.69 CHI3L1 expression is induced by a high-fat diet and contributes to the genesis of obesity and asthma by the inhibition of sirt1 expression.74 CHI3L1 is expressed in a time-dependent manner during the differentiation and maturation of monocyte-derived DCs, and distributed in the cytoplasm and nucleus of both immature and mature DCs.75