Likewise, CHI3L1 expression has been positively correlated with the motility and invasiveness of prostate cancer cells (DU145 and PC3), where it directly affects cancer metastasis by regulating the expression of EMT genes.128 Both ECM degradation and reduction in cell-ECM adhesion contribute to malignant transformation and local invasiveness. This evidence concerns the gene CHI3L1 and Familial prostate cancer.