CHI3L1 and venous thromboembolism: It has been reported that baseline plasma CHI3L1 level is significantly associated with incident thromboembolic stroke with a magnitude of effect.200 Similarly, high CHI3L1 levels are associated with a 2-fold increased risk of venous thromboembolism.201 Additionally, CHI3L1 is associated with hypertension incidence only among men in China.