CHI3L1 and neoplasm: In summary, considering the multiple roles of CHI3L1 in oncogenesis, the direct neutralization of CHI3L1 will reduce tumor-associated inflammatory response, ECM degradation, angiogenesis, and tumor metastasis, thereby inhibiting tumor progression.150,261 Moreover, considering the binding partners involved in CHI3L1 signaling, reagents targeting and disrupting these interactions warrant further investigation in future cancer research and clinical trials.