CHI3L1 and breast cancer: In mammary tumor-bearing mouse model, chitin treatment reduced the induction of proinflammatory mediators (CCL2, CXCL2, and MMP-9), tumor growth, and pulmonary metastasis induced by CHI3L1 overexpression.28 Moreover, resveratrol, a natural phenol, decreased the activity of the CHI3L1 promoter, reducing both mRNA transcription and protein expression, thereby repressing the growth, proliferation, and invasion of U87 MG cells in vitro.258