To clarify the cellular sources of IL-20 receptors in the pancreatic tumor microenvironment, we performed IHC staining to analyze the expression of IL-20 receptors (IL-20R1, IL-20R2, and IL-22R1) in tumor and nontumor stromal tissue samples from patients and mice with pancreatic cancer. This evidence concerns the gene IL20RB and familial pancreatic carcinoma.