Indeed, the combination of IL-20 blockade with anti-PD-1 therapy showed remarkable antitumor efficacy, as significantly reduced tumor weights were observed for mice treated with the combination of 7E and the anti-PD-1 antibody compared to mice treated with either 7E or the anti-PD-1 antibody alone, demonstrating synergistic efficacy in PDAC. This evidence concerns the gene IL20 and neoplasm.