Among the respiratory failure patients, young adults (aged 50 years and lower) with previously mild comorbidities have a relatively high rates.3 The respiratory failure is concomitant with characteristic CT scan, lymphocytopenia, high prothrombin time, and D-dimer levels.4 This biphasic evolution suggests a dysregulated inflammatory host response driven by virus resulting in an imbalance between pro- and anti-inflammatory mediators.5 However, the immunological features and mechanisms involved in COVID-19 severity are unclear. This evidence concerns the gene F2 and respiratory failure.