LncRNA BCAR4 is highly expressed in advanced breast cancer patients and contributes to breast cancer metastasis mediated by chemokine-induced binding of BCAR4 to two transcription factors (SNIP1 and PNUTS) with extended regulatory consequences, licensing the activation of a noncanonical hedgehog/GLI2 transcriptional program that promotes cell migration39. The gene discussed is GLI2; the disease is breast carcinoma.