2- To determine the salivary cytokine profiles of IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ and IL- 17 among COVID-19 patients subjected to 1% Hydrogen peroxide, 0.2% Povidone-Iodine, 2% hypertonic saline or Neem extract (Azardirachta indica) based gargles.<h4>Trial design</h4>This will be a parallel group, quadruple blind-randomised controlled pilot trial with an add on laboratory based study.<h4>Participants</h4>A non-probability, purposive sampling technique will be followed to identify participants for this study. This evidence concerns the gene IFNG and COVID-19.