On the one hand, previous literatures have said that GDF5 rs143383 polymorphisms C allele is a protective factor for the susceptibility of knee osteoarthritis among Caucasian populations (OR = 0.74, P < 0.001) and Asian populations (OR = 0.87, P = 0.004) [9]. The gene discussed is GDF5; the disease is osteoarthritis, knee.