SOD1 and amyotrophic lateral sclerosis: Inclusions containing misfolded SOD1 in degenerating spinal motor neurons (MNs) are a hallmark of SOD1-mediated ALS in patients carrying SOD1 mutations and in transgenic (Tg) models over-expressing mutant and/or human wild-type SOD1 (hSOD1Wt) [10, 19, 21, 42].