Tumour-associated macrophages (TAMs) induce increased expression of glucose transporters and glycolytic enzymes by stabilizing HIF-1α, including glucose transporter 1 (GLUT1), glucose transporter 3 (GLUT3), hexokinase-2 (HK2) and lactate dehydrogenase (LDH), to increase glucose uptake and lactate formation in breast cancer. The gene discussed is HK2; the disease is breast carcinoma.