A recent study showed that NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 4-like 2 (NDUFA4L2) is highly overexpressed in hypoxic liver cancer cells, and it has been confirmed that NDUFA4L2 is regulated by HIF-1α in HCC cells. This evidence concerns the gene COXFA4L2 and hepatocellular carcinoma.