ABCC8 and coronary artery disorder: In particular, channel defects (ChD), deriving from mutations of the K-ATP channel, represent about 36% of all CH cases [5] and affect ABCC8 and KCJN11 genes, which codify respectively for Sulfonylurea Receptor 1 (SUR1) and Kir6.2 (that are K-ATP channel subunits).