This finding could be linked to ABCC8 role in susceptibility to obesity, as already reported in Type 2 Diabetes subjects [23], probably facilitated by hyperinsulinism; however, it is known that some ABCC8 Single Nucleotide Polymorphisms seem to be protective against metabolic syndrome [24]. This evidence concerns the gene ABCC8 and obesity due to melanocortin 4 receptor deficiency.