Factors found to influence the prognosis at initial diagnosis of MLS include patient age, tumor size, tumor depth, the surgical margins achieved, and morphological factors such as grading, necrosis and mitotic rate, proliferation index (MiB-1, Ki-67 immunostain), and P53 overexpression [5, 9, 11, 14]. This evidence concerns the gene MKI67 and neoplasm.