In the multivariate analyses of all patients, tumor factors such as larger tumor size (≥4 cm), multifocality, micro or major vessel invasion, and gross morphology of the infiltrative type, along with well-known clinical markers of hepatic function such as albumin and prothrombin time, were independently associated with worse OS in all HCC-resected patients (all, p < 0.05) (Table 2). Here, F2 is linked to hepatocellular carcinoma.