TRPM7 and neurodegenerative disease: It may protect neurons from neurodegeneration also in vivo because it has been reported that gain-of-function mutation in SLC41A1, that leads to enhanced Mg2+ release from cytosol, and mutation in a Mg2+ and Ca2+ permeable channel, TRPM7, that attenuates cellular Mg2+ uptake, are associated with the pathogenesis of neurodegenerative diseases in human brain [50,51].