MMP2 and Hepatic fibrosis: Jiang et al. [54] revealed that cyanidin-3-O-β-glucoside (extracted from the skin of black rice—Oryza sativa L. indica) had a protective effect on the CCl4-induced liver fibrosis in mice and on the activation of HSC isolated from mice by downregulation of the collagen type I gene, as well as an increase in the expression of MMP-2.