Age (OR, 1.031; 95% CI, 1.016–1.047), angina (OR, 0.416; 95% CI, 0.187–0.923), cardiac etiology (OR, 0.274; 95% CI, 0.159–0.471), downtime (OR, 1.055; 95% CI, 1.039–1.070), shockable rhythm (OR, 0.237; 95% CI, 0.148– 0.381), SOFA score (OR, 1.089; 95% CI, 1.008–1.176), pH (OR, 0.107; 95% CI, 0.034–0.334), peak CRP (OR, 1.023; 95% CI, 1.009–1.038), pre-TTM temperature (OR, 0.737; 95% CI, 0.633–0.857), seizure (OR, 5.984; 95% CI, 3.655–9.797), and infection (OR, 1.573; 95% CI, 1.043–2.372) were independently associated with unfavorable neurologic outcomes. The gene discussed is CRP; the disease is infection.