In addition, the coumarin-derivate compound 5-methoxypsoralen (Bergapten) upregulated PTEN and p38 MAPK/NF-Y pathways and inactivated Akt/mTOR pathway resulting in autophagy and the inhibition of the survival of breast cancer cells (MCF-7 and ZR-75). This evidence concerns the gene AKT1 and breast cancer.