ATF4 and breast cancer: Conversely, it was reported that prepubertal and lifetime genistein consumption improved the sensitivity of mammary tumors to tamoxifen therapy, by reducing autophagy-related genes (GRP78, IRE1α, ATF4 and Beclin 1) in (9,10-dimethylbenz[a]anthracene (DMBA)-induced mammary tumors in female Sprague–Dawley rats fed with AIN93G diet supplemented with 500 ppm genistein) [179].