SQSTM1 and malignant colon neoplasm: Recently, it was also shown that Grias nuberthii extract (20–50 μg/mL), which contains lupeol, 3′-O-methyl ellagic acid 4-O-β-D-rhamnopyranoside, and 19-α-hydroxy-asiatic acid monoglucoside, inhibited the growth of human colon cancer (RKO and SW613-B3) cells by inducing autophagy only (increase in Beclin 1, LC3 II and decrease in p62) [241].