Xiaping et al. demonstrated the development of autophagosomes in apigenin treated cisplatin-resistant colon cancer HT-29 cells (15–60 μM), indicating that this flavonoid induced autophagic process, as corroborated by the upregulation of the autophagy-related proteins Beclin 1 and LC3 II and the suppression of p62 expression [117]. Here, SQSTM1 is linked to malignant colon neoplasm.