The activation of apoptosis, as well as a nonprotective autophagy and the generation of autophagic flux, mediated by the inhibition of the PI3K/Akt/mTOR pathway, were demonstrated for a novel hybrid of a 3-benzyl coumarin seco-B-ring derivative and phenylsulfonylfuroxan (50 nM) in NSCLC A549 cells [192]. Here, AKT1 is linked to non-small cell lung carcinoma.