In the same cancer cells resistant to etoposide (A549RT-eto), feroniellin A (FERO; 0.05–1 mM), a novel furanocoumarin, induced autophagy, characterized by the conversion of LC3 I, the induction of GFP-LC3 puncta structures, the increase in Beclin 1 and ATG5 expression and the inhibition of mTOR. Here, MAP1LC3A is linked to cancer.