Similarly, isogambogenic acid (2.5–10 μM) induced only autophagic cancer cell death and not apoptosis in human NSCLC cells (A549 and H460) and in a xenograft model (20 mg/kg, i.v., every 2 days, for 24 days), through the inhibition of the Akt/mTOR pathway. This evidence concerns the gene AKT1 and non-small cell lung carcinoma.