The involvement of yes-associated protein (YAP) in the regulation of the autophagic flux induced by curcumin in colon cancer cells (SW620, HCT-116) was demonstrated by Zhu et al. Indeed, curcumin (10–30 μM) induced moderate cytotoxicity, an increase in LC3 protein, a decrease in p62 expression and led to a reduction in YAP expression [214]. Here, SQSTM1 is linked to colonic neoplasm.