In addition, the in vivo administration of quercetin (50 mg/kg, intraperitoneally (i.p.), twice daily for a month) was able to reduce the size of the tumors and to reduce the level of the protein Beclin 1 and of phospho-Akt/Akt ratio in tumor tissues in a breast cancer xenograft mouse model [60]. This evidence concerns the gene BECN1 and neoplasm.