A similar induction of autophagy as well as apoptosis was demonstrated for honokiol (10–20 μg/mL) in osteosarcoma cells (MG-63), through the inhibition of the PI3K/Akt/mTOR pathway [257] in human thyroid cancer cells (ARO, WRO, SW579; 20–60 μM) and in a xenograft nude mouse model (5 or 15 mg/kg, oral, every 3 days) [258]. This evidence concerns the gene AKT1 and thyroid gland carcinoma.