Luteoloside, a naturally flavonoid isolated from the medicinal plant Gentiana macrophylla, also induced autophagic cell death (60 μM) in A549 and H292 NSCLC cells by inhibiting the Akt/mTOR/p70S6K signaling pathway and this resulted in the overexpression of Beclin 1 and LC3 II and in a reduced expression of p62 [145]. The gene discussed is AKT1; the disease is non-small cell lung carcinoma.