Conversely, Pellerito et al. recently reported that a novel synthetic derivative of ferulic acid, tributyltin(IV) ferulate (400 nM) inhibited the proliferation of colon cancer cells (HCT-116, HT-29, Caco-2) by inducing G2/M cell cycle arrest and autophagic cell death, as shown by the formation of autophagic vacuoles and the increase in LC3 II and p62 [252]. The gene discussed is SQSTM1; the disease is malignant colon neoplasm.