BECN1 and ovarian cancer: Similarly, Ning et al. reported that pinoresinol inhibited, in vitro (10–40 μM) and in vivo (40 mg/kg, i.p., thrice a week, for 6 weeks), ovarian cancer cell (SKOV-3) growth by inducing autophagy, with the formation of autophagic vesicles, an increase in LC3 II and Beclin 1 expression, a decrease in p62 expression, and the inhibition of cell invasion and the RAS/MEK/ERK pathway [269].