The combined treatment with luteolin (20 μM) and silibinin (50 μM) suppressed the autophagic activity, as demonstrated by the downregulated expression of LC3 I, LC3 II and Beclin 1, and induced the apoptotic process in U87MG and T98G glioblastoma cells [138]. This evidence concerns the gene BECN1 and glioblastoma.