Moreover, it was reported that the combination of indol-3-carbinol (I3C; 300 μM), from cruciferous vegetables, and genistein (40 μM) inhibited the survival of human colon cancer HT-29 cells by inducing apoptosis and autophagy through the downregulation of Akt and mTOR. The gene discussed is AKT1; the disease is malignant colon neoplasm.