Curcumin (20 μM), combined with the mTORC1/2 inhibitor PP242, induced cell death in human cancer cells (renal carcinoma: Caki, ACHN, A498; glioma: U87MG; breast carcinoma: MDA-MB-231), by downregulating Rictor and Akt protein levels. The gene discussed is AKT1; the disease is cancer.