NOD1 and atherosclerosis: Although no significant differences were found between the groups in the lesion area of the aortic valve (Figure 1a), the planimetric analysis of the aorta stained with ORO showed an approximate reduction of 15% in the atheroma of the aortic arch in Apoe−/−Nod1−/− mice compared to controls (Figure 1b), thus confirming our previous results on the preventive role of Nod1 deletion in early atherosclerosis [9].