Although the metabolic roles of Tip60 in prostate cancer remain to be elucidated, several studies have indicated that Tip60 affects cell survival indirectly by modulating key regulators involved in the process of metabolic stress and rewiring, such as c-Myc, HIF-1α and p53, in other cancer types [12,13,51,52]. The gene discussed is KAT5; the disease is cancer.