PFKFB2 and Familial prostate cancer: Additionally, some studies have identified several key glycolytic enzymes that were upregulated by androgens in prostate cancer models, including hexokinase (HK) 1 and 2, phosphofructokinase (PFK), pyruvate kinase (PK) and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB2) [9,31].