Although the significance found in the 3xTg-AD group was not reached, we observed a tendency for the protection from the loss of volume associated with aging in the cortex, cerebrum, and the whole brain, and diminished the 6E10+ intensity, amyloid load, and IL-6 values in both the hippocampus and, especially, the cortex [24]. The gene discussed is IL6; the disease is Alzheimer disease.