Phosphorylated tau was also increased in 3xTg-AD compared to NTg mice (U-value = 0; p = 0.0079; r = 1)) but no effect of scFv-h3D6 treatment was observed (U-value = 10; p = 0.8016; r = 0.12) (Figure 4D). This evidence concerns the gene MAPT and Alzheimer disease.