MAPT and Alzheimer disease: When focusing on tau and the effect of scFv-h3D6, the 3xTg-AD, but not NTg mice, showed strong labeling for mAb HT7 (U-value = 0; p = 0.0079; r = 1), indicative of high levels of total tau, which were partially decreased after treatment (U-value = 4; p = 0.0952; r = 0.68) (Figure 4A,B).