APOE and Alzheimer disease: Although apoE reduction was previously reported after scFv-h3D6 treatment in 5-month-old 3xTg-AD mice [21], there was a small decrease in the median value at 22 months of age that never tended to be close to the values of the NTg group (U-value = 10; p = 0.6667; r = 0.2).