CD274 and neoplasm: Table 1 represents the association between clinicopathologic characteristics and PD-L1+ cells at baseline. The rate of PD-L1+ cells at baseline differed significantly according to the tumor location. For patients with low level of PD-L1+ cells, 19% of tumors were located within 5 cm from the anal verge, 61% between 5 and 10 cm, and 19% >10 cm from the anal verge vs. 50%, 31%, and 19%, respectively, for patients with high level PD-L1+ cells (p = 0.01). This was not found after treatment on surgical specimens (Table 1).