Our work has revealed that a large number of lncRNAs are differentially regulated by TMZ in chemo-sensitive and resistant GSCs, as well as in non-malignant NSCs, and identified key lncRNAs that may be linked to the regulation of DDR, apoptosis, and EGFR signaling in GBM, as part of co-expression networks with mRNAs and other small RNAs. Here, EGFR is linked to glioblastoma.