The formation of IgG-immune complexes (IgG-IC), including anti-LL-37 antibodies (Abs), and their deposition in synovial tissues of PsA can fuel this vicious inflammatory circle, and also induce a type-I signature via TLR7/8/9, as observed in systemic LE (SLE) [20]. The gene discussed is TLR7; the disease is systemic lupus erythematosus.