From the nine types of pharmacological agents currently used to treat T2D (sulfonylureas, meglitinides, biguanides, thiazolidinediones, alpha glucosidase inhibitors, DPP-4 inhibitors, bile acid sequestrants, dopamine agonists, and sodium–glucose transport protein 2 inhibitors), the compounds obtained from Mexican hypoglycemic plants share one or more of their mechanisms of action. The gene discussed is DPP4; the disease is type 2 diabetes mellitus.