The molecular evidence showed the association of various signaling pathways with glioma development, including Notch, phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt)/rapamycin (mTOR), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF/kB) signaling pathways [2,3,4]. Here, AKT1 is linked to central nervous system cancer.