In further support of our findings, T. gondii was found to decrease resistance of colorectal adenocarcinoma-derived Caco-2 cells and impair the integrity of the intestinal mucosa via disruption of TJ proteins, including a decrease in occludin and ZO-1 expression, and redistribution of claudin-1, occludin, and ZO-1 in the cytoplasm of intestinal epithelial cells [39]. The gene discussed is CLDN1; the disease is colorectal adenocarcinoma.