More recently, we found that curcumin, at the concentration of 5 μM, protected neuroblastoma (SH-SY5Y) cells against H2O2-induced cell death by modulating of Small Ubiquitin-like Modifier (SUMO)-1-JNK(c-Jun N-terminal kinases)-TAU axis, indicating that curcumin might be a promising therapeutic agent against not only oxidative stress, but also pathologies characterized through SUMO, JNK, and Tau alterations in many neurodegenerative diseases [126]. The gene discussed is MAPK8; the disease is neurodegenerative disease.