Increased levels of sHSP expression were identified in breast (HspB1, HspB2, HspB5) [25,26,27,28,29], cervical (HspB1) [31], colorectal (HspB1, HspB5) [32,33], gastric (HspB1, HspB5, HspB8) [36,37,38], glioblastoma (HspB1, HspB5) [55,56], larynx (HspB1, HspB5) [39,40], liver (HspB5) [42], lung (HspB1, HspB5) [43,45], oral (HspB5) [46], osteosarcoma (HspB5) [57], ovarian (HspB8) [48], prostate (HspB1) [51], renal (HspB1, HspB5) [52,53], and testis (HspB9) [35] cancers. The gene discussed is HSPB8; the disease is osteosarcoma.