HSPB1 and breast cancer: Furthermore, HspB1 exhibited an alteration of its degree of phosphorylation when treatment with vinblastine, paclitaxel, and doxorubicin in breast cancer cells and serine 59 phosphorylation of HspB1 induced apoptosis of vinblastine-treated breast cancer cells [73], suggesting that specifically inducing the phosphorylation of HspB1 can improve therapeutic outcomes by circumventing the drug resistance of breast cancer.