Subsequently, numerous studies have demonstrated that overexpression of HspB5 in breast cancer cells increased cell migration and invasion [28], and HspB1 silencing in colorectal [98], prostate [99], ovarian [100], and liver [101] cancers or head and neck squamous cell carcinoma [102], HspB8 silencing in breast cancer [61], or HspB5 silencing in colorectal [103] and renal [53] cancers inhibit migration and/or invasion of cancer cells. Here, CRYAB is linked to head and neck squamous cell carcinoma.