CDKN2A and colorectal cancer: The most significantly enriched pathways based on a Z-score > 2 or <−2 are presented in Figure 2B, which demonstrate the positively enriched pathways were p14/p19 ARF and the endocabinoid pathways, while the negatively enriched pathways were the colorectal cancer metastasis pathway (Z = −2.80) and ovarian cancer signalling pathways (Z = −2.54).