Principally, Epstein–Barr virus- (EBV-) immortalized lymphoblastoid cell lines are not a disease-specific cell type when we consider that PD is characterized by the loss of vmDANs of the SNc, it is also necessary to consider that the functional role of the alpha-synuclein protein may diverge between those cell types. The gene discussed is SNCA; the disease is Parkinson disease.