Over 10 years later, Beffagana et al. identified two variants in untranslated regions (UTR) of TGFB3; a 5′ UTR mutation segregating in a large ARVC family and a 3′ UTR mutation associated with an unrelated ARVC patient [110]. This evidence concerns the gene TGFB3 and arrhythmogenic right ventricular cardiomyopathy.