Their affects involve COX-dependent or COX-independent mechanisms, and they act on different pathways such as Wnt/β-catenin and Hippo or by regulation of oxidative stress and the expression of Granzyme B. To date, there are numerous papers in the literature that describe different mechanisms of action of ω-3PUFAs in CRC, as summarized in Table 1. The gene discussed is GZMB; the disease is colorectal carcinoma.