GRIN1 and epilepsy: Downregulated genes in these functional categories included many channels or receptors that may alter action potential burst duration, including inwardly rectifying potassium channels (Kcnj3, Kcnj6, and Kcnj9), voltage-gated sodium channels linked to epilepsy (Scn1a), ionotropic glutamate receptors (e.g., Gria3, Grik1, Grin1), and GABA receptor subunits (e.g., Gabbr2, Gabra5, Gabrb3, Gabrg1, Gabrg3).