BRD7, a subunit of PBAF-specific SWI/SNF complex and functioning as a transcriptional cofactor for tumor suppressor protein p53, has been described as a tumor suppressor gene in many cancers, such as HCC [24], nasopharyngeal carcinoma (NPC) [45] and colorectal cancer (CRC) [46]. The gene discussed is SMARCA1; the disease is colorectal carcinoma.