Moreover, in univariate Cox regression analysis for DFS, HCC patients with vascular invasion (HR = 1.687, 95% CI: 1.288-2.210, and P < 0.001), high pathologic stage (HR = 1.731, 95% CI: 1.450-2.066, and P < 0.001), and high mRNA expressions of BRD2 (HR = 1.479, 95% CI: 1.092-2.003, and P = 0.011), BRD4 (HR = 1.608, 95% CI: 1.187-2.177, and P = 0.002), BRD8 (HR = 1.905, 95% CI: 1.404-2.585, and P < 0.001) and BRD9 (HR = 1.794, 95% CI: 1.323-2.434, and P < 0.001), had worse DFS (Supplementary Table 3). This evidence concerns the gene BRD9 and hepatocellular carcinoma.