Tumor infiltrations of neutrophils [12], tumor-associated macrophages (TAMs) [13] and regulatory T cells (Tregs) [14] are associated with poor prognosis in HCC patients while infiltrating B cells [15], CD8+ cytotoxic T lymphocytes (CTLs) [16] and dendritic cells (DCs) [17] predict favorable clinical outcome of HCC. This evidence concerns the gene CD8A and hepatocellular carcinoma.