BCR and chronic myelogenous leukemia, BCR-ABL1 positive: In this study, we evaluated the antiproliferative effects of shikonin on both TKI-sensitive and TKI-resistant CML cells harboring the Bcr/Abl fusion gene and identified, by transcriptomics and reporter expression analyses, an miRNA-based mechanism regulating MLKL expression and necroptosis onset in CML cells.