Urine ketone assessment is insufficient to screen for the diagnosis because it only measures acetoacetate when the predominant ketone body in eDKA is B-hydroxybutyrate.14 After immediate cessation of SGLT-2 inhibitors, the treatment for eDKA is virtually identical to that of classic DKA, with the exception that dextrose-containing IV fluids must be initiated at the same time as insulin to prevent hypoglycemia.15 This evidence concerns the gene INS and Hypoglycemia.